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Aim the needle toward the glass side wall of the vial rather than spraying directly onto the powder

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Circulating Gla domain hemostatic proteins Procoagulant coagulation factors: Factors II, VII, IX, and X Anticoagulant factors: Protein C, Protein S, Protein Z Tissue and vascular Gla domain proteins Bone metabolism, cell migration: Osteocalcin, Periostin, MGP(matrix Gla protein), Vascular smooth muscle function, cell proliferation: MGP, Gas6 (growth arrest specific protein-6) Diagnosis of Vitamin K-dependent Coagulopathy Coagulation Tests and Sample requirements Coagulation screening tests and specific assay of the vitamin K-dependent coagulation factors are direct measures of the cause of bleeding in vitamin K deficiency states